warnings

What is the most important information I should know about Ampyra (Dalfampridine)?

You should not use this medicine if you are allergic to dalfampridine or 4-aminopyridine, or if you have:

moderate to severe kidney disease; or
if you've ever had a seizure.

Dalfampridine can cause a seizure, even if you never had one before. Your risk may also be higher if you have kidney problems or are older than 50.

Tell your doctor if you have ever had:

kidney disease; or
if you also take a form of this medicine obtained from a compounding pharmacy (fampridine, or 4-aminopyridine).

Older adults may be more sensitive to the effects of this medication.

It is not known if dalfampridine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using this medicine.

Not approved for use by anyone younger than 18 years old.

Side Effects

What are the side effects of Ampyra (Dalfampridine)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop taking dalfampridine and call your doctor right away if you have a seizure.

Call your doctor at once if you have:

pain or burning when you urinate; or
relapse or worsening of MS symptoms.

Common side effects may include:

weakness, MS relapse;
painful urination;
dizziness, balance problems;
numbness or tingling;
sleep problems (insomnia);
nausea, constipation, upset stomach;
stuffy nose, sinus pain, sore throat; or
headache, back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Dosage Guidelines & Tips

How to take Ampyra (Dalfampridine)?

Use Ampyra (Dalfampridine) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Taking too much dalfampridine may increase your risk of seizure. Space your doses 12 hours apart. Do not take more than 2 tablets in 24 hours.

You may take dalfampridine with or without food.

Swallow the tablet whole and do not crush, chew, or break it. Breaking the pill may cause too much of the drug to be released at one time which can increase your risk of a seizure.

Do not use a tablet that has been crushed or broken.

Store at room temperature away from moisture and heat. Do not use past the expiration date on the label.

What should I do if I missed a dose of Ampyra (Dalfampridine)?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.