Aripiprazole is an antipsychotic medicine that is used to treat schizophrenia in adults and children at least 13 years old.

Aripiprazole is also used in children at least 6 years old to treat Tourette's disorder, or irritability related to autistic disorder.

Aripiprazole is used alone or with a mood stabilizer medicine to treat bipolar I disorder (manic depression) in adults and children at least 10 years old.

Aripiprazole is used with antidepressant medication to treat major depressive disorder in adults.

Aripiprazole may also be used for purposes not listed in this medication guide.

warnings

What is the most important information I should know about Abilify (Aripiprazole)?

You should not take aripiprazole if you are allergic to it.

Aripiprazole may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

Tell your doctor if you have ever had:

heart problems or a stroke;
high or low blood pressure;
diabetes (in you or a family member);
seizures; or
low white blood cell (WBC) counts.

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.

The liquid form (oral solution) of this medication contains sugar. Before taking aripiprazole oral solution, tell your doctor if you have diabetes.

Aripiprazole can cause high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels carefully.

The orally disintegrating tablet form of aripiprazole contains phenylalanine and could be harmful if you have phenylketonuria (PKU).

Taking antipsychotic medicine in the last 3 months of pregnancy may cause serious problems in the newborn. Tell your doctor right away if you get pregnant. Do not stop the medicine without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of aripiprazole on the baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

Side Effects

What are the side effects of Abilify (Aripiprazole)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor right away if you have new or sudden changes in mood or behavior, including new or worse depression or anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, more active or talkative, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

severe agitation, distress, or restless feeling;
twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
mask-like appearance of the face, trouble swallowing, problems with speech;
seizure (convulsions);
severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;
low blood cell counts--fever, chills, sore throat, weakness, easy bruising, unusual bleeding, purple or red spots under your skin; or
high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.

Common side effects may include:

blurred vision;
increased saliva or drooling;
muscle stiffness;
uncontrolled muscle movements, shaking, anxiety, feeling restless;
weight gain;
nausea, vomiting, constipation;
increased or decreased appetite;
headache, dizziness, drowsiness, feeling tired;
sleep problems (insomnia); or
cold symptoms such as stuffy nose, sneezing, sore throat;

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Interactions

What drugs and food should I avoid while taking Abilify (Aripiprazole)?

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Avoid drinking alcohol. Dangerous side effects could occur.

While taking aripiprazole, you may be more sensitive to very hot conditions. Avoid becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise.

Dosage Guidelines & Tips

How to take Abilify (Aripiprazole)?

Use Abilify (Aripiprazole) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Aripiprazole can be taken with or without food.

Swallow the regular tablet whole and do not crush, chew, or break it. Do not split the orally disintegrating tablet.

Measure liquid medicine with the supplied measuring device (not a kitchen spoon).

Allow the orally disintegrating tablet to dissolve in your mouth without chewing.

Your doctor will need to check your progress on a regular basis.

If you also use antidepressant medicine, do not stop using it suddenly or you could have unpleasant symptoms. Ask your doctor before stopping the antidepressant.

Store at room temperature away from moisture and heat. Aripiprazole liquid may be used for up to 6 months after opening, but not after the expiration date on the medicine label.

What should I do if I missed a dose of Abilify (Aripiprazole)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Get your prescription refilled before you run out of medicine completely.